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EMF use for inflammation needs to be optimized so that exposure will lead to long-lasting, therapeutically relevant outcomes. Pulse-burst-modulated higher frequency fields seem to be much more effective than other frequency signals, and therefore produce improved therapeutic outcomes. While particular types of signals may be most effective, a positive response is often seen to various kinds of magnetic stimuli. There appear to be similar effects on lymphocytes using pulsed bone healing fields, versus sinusoidal power line frequency fields. Pulsed PEMF’s with intensities from 5-25 MilliTesla had no effects on normal T cells. This means there is no apparent damage to normal lymphocytes.

Inflammatory T cells produce interleukin-2 (IL-2), which stimulates growth of T cells. When IL-2 levels are high enough, it increases desired early elimination of these chronic inflammatory cells. Cells exposed to pulsed PEMF’s can make up to a threefold increase in IL-2. There appear to be EMF intensity windows, but these have not been well defined. Frequency windows have been found to vary across different types of tissue cells in the body. The frequency ranges appear to be quite narrow for bone cells. For lymphocytes the frequency windows seem to be broader. Even 5-100 hertz, 0.15 mT signals modulate calcium flux in lymphocytes, 50 Hz PEMF’s having the greatest effect. Frequency fields, combined with parallel static magnetic fields have also been found to have action. It is important to know that PEMF’s affect all lymphocytes, including B cells and T cells and other human lymphoid cell lines.